Yes, that should be safe as well. They are all safe to use together. The short answer is yes, generally, gabapentin and melatonin can be given together to dogs, often with beneficial effects. In fact, a combination of these two medications is sometimes used intentionally, such as in the chill protocol , a management strategy designed to help dogs cope with stressful situations like veterinary visits. Yes, gabapentin and melatonin can generally be mixed for dogs, and in many cases, this combination is even beneficial.
Several types of drugs commonly prescribed to pets increase serotonin levels within the brain, and when they are used together, their combined effect may result in a dangerous and possibly fatal reaction called serotonin syndrome. However, this approach should always be under the guidance of a veterinarian. It is possible that these potential adverse effects of acepromazine were mitigated by its combination with gabapentin and melatonin. Oral melatonin is unlikely to be the cause of the increased sedation levels observed. A recent study 27 reported no sedation in dogs receiving 3 mg (dogs < 15 kg) and 6 mg (dogs > 15 kg) of melatonin po. Generally, there are no known severe interactions between gabapentin and melatonin. Both can cause drowsiness, so monitor her for excessive sedation. No significant interactions are known between meloxicam and melatonin. However, always be cautious with combining medications.
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